The field of onconephrology encompasses the broad spectrum of kidney disorders that can arise in patients with cancer. Beyond cancers of the kidney, nonrenal cancers can have renal complications, and anticancer therapies, including chemotherapy, targeted anticancer agents and immunotherapy can have adverse renal effects, leading to the development of fluid, electrolyte and acid–base disorders, as well as acute kidney injury and chronic kidney disease.
Moreover, renal impairment can alter the excretion and metabolism of anticancer agents, necessitating dose adjustment. A clearer understanding of cancers and anticancer therapies that affect the kidney is essential to improve patient care and to facilitate the development of new, nontoxic treatments. This series of articles aims to examine the complex relationship between cancer and the kidney across the spectrum of onconephrology.